Usage of U7 snRNA in gene therapy of hemoglobin S disorder - is it feasible?
نویسنده
چکیده
OBJECTIVE Hemoglobin (Hb) S disorder [beta6(A3)Glu-->Val, GAG-->GTG] is an important hemoglobinopathy with the highest endemicity in Africa. METHODS Here, the author performs a basic bioinformatics gene ontology study to assess the effect of co-expression between nucleic acid sequence for human Hb S beta globin chain and U7.623. RESULTS According to this study, the analytical results show that fully recovery of hemoglobin in both function and biological process can be got. CONCLUSION Here, the author proposed that U7 snRNA might be a probable tool for treatment by gene therapy approach in Hb S disorder.
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ورودعنوان ژورنال:
- Turkish journal of haematology : official journal of Turkish Society of Haematology
دوره 26 3 شماره
صفحات -
تاریخ انتشار 2009